Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis
نویسندگان
چکیده
منابع مشابه
Sporadic amyotrophic lateral sclerosis
This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis that astrocytes may be the cells which serve as targets for the harmful action of a still unknown e...
متن کاملUltrastructural mitochondrial abnormalities in patients with sporadic amyotrophic lateral sclerosis.
A large number of neurodegenerative diseases are caused by impairment of mitochondrial function. Mutations in genes that encode proteins responsible for the shape and dynamics of mitochondria have been associated with some genetic neurodegenerative diseases, which implies that mitochondrial shape plays an important role in the health of neurons and muscle. Neurons are highly dependent on mitoch...
متن کاملSporadic amyotrophic lateral sclerosis. A clinical analysis
Objective. To illustrate that sporadic amyotrophic lateral sclerosis (ALS) may be caused by ischemia in the intraparenchymal territory of the anterior spinal artery (ASA) and/or anterior-ventral spinal arteries (AVSAs). Case report. A 56-year-old woman presented clinical data of spinal and bulbar forms of ALS. Previously she was attended in several neurological centers. Results. In 2002 the pat...
متن کاملGenetics of sporadic amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized clinically by rapidly progressive paralysis leading ultimately to death from respiratory failure. There is substantial evidence suggesting that ALS is a heritable disease, and a number of genes have been identified as being causative in familial ALS. In contrast, the genetics of the much commoner sporadic for...
متن کاملIs Amyotrophic Lateral Sclerosis a Mitochondrial Channelopathy?
SOD1 is a cause of the fatal, paralytic disorder ALS. Although mechanisms underlying mutant SOD1 neurotoxicity remain uncertain, this protein associates with mitochondria. In this issue of Neuron, Israelson et al. show that mutant SOD1 binds and inhibits the mitochondrial channel VDAC1. This finding sheds light onto possible molecular links between mutant SOD1, mitochondrial dysfunction, and sp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Epigenetics
سال: 2020
ISSN: 1868-7075,1868-7083
DOI: 10.1186/s13148-020-00933-2